Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methimazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPO | P22079 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methimazole SCHEMBL1816808 | 0.89 | LPO (0.50) | LPOFDPSGAAKMT2AMEN1 | |
| Methimazole SCHEMBL41647 | 0.89 | — | — | |
| Methimazole SCHEMBL6189739 | 0.86 | — | — | |
| Methimazole SCHEMBL17287217 | 0.86 | — | — | |
| Methimazole SCHEMBL2267872 | 0.86 | — | — | |
| Methimazole SCHEMBL28774524 | 0.86 | — | — | |
| Methimazole SCHEMBL11566410 | 0.86 | — | — | |
| Methimazole SCHEMBL11405758 | 0.78 | LPO (0.41) | LPOFDPSKMT2AMEN1HTT | |
| Methimazole SCHEMBL10436346 | 0.78 | LPO (0.38) | LPOHTT | |
| Methimazole SCHEMBL25206387 | 0.75 | LPO (0.39) | LPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107144649-A | Biodegrading process based on ultrasonic or ultraviolet enhanced sulfamethyldiazine | 西安理工大学 | 2017-09-08 | — | — | CN | disclosed |