Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 2/20 | 0.30 |
| ▸ | EDNRA | P25101 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561 | 0.81 | LPAR1 (0.34) | MAPTEDNRBEDNRACYP2C9TDP1 | |
| SCHEMBL7689 | 0.81 | CYP1A2 (0.31) | CYP1A2CYP3A4CYP2C9CYP2C19TDP1 | |
| SCHEMBL1448 | 0.79 | BRD4 (0.35) | TP53MAPTBRD4EDNRBEDNRA | |
| SCHEMBL1933 | 0.78 | EPHX1 (0.34) | TP53MAPTBRD4 | |
| SCHEMBL11802 | 0.78 | CYP1A2 (0.33) | TP53MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6652 | 0.74 | MEN1 (0.38) | TP53BRD4EDNRBEDNRATDP1 | |
| SCHEMBL1853 | 0.73 | EPHX1 (0.41) | BRD4 | |
| SCHEMBL11401 | 0.72 | PPARA (0.31) | CYP1A2CYP3A4CYP2C9CYP2C19TDP1 | |
| SCHEMBL18597743 | 0.71 | ALDH1A1 (0.38) | TP53MAPTBRD4EDNRBEDNRA | |
| SCHEMBL14633 | 0.71 | BRD4 (0.31) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |