Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.32 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.32 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.32 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | EDNRB | P24530 | 3/20 | 0.32 |
| ▸ | EDNRA | P25101 | 3/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6652 | 0.85 | MEN1 (0.38) | EDNRBEDNRASMN1; SMN2NPC1RAB9A | |
| SCHEMBL1933 | 0.84 | EPHX1 (0.34) | LPAR1LPAR3NR1H4GAAMAPT | |
| SCHEMBL11409 | 0.81 | TP53 (0.31) | CYP2C9EDNRBEDNRAMAPTTDP1 | |
| SCHEMBL7387 | 0.80 | NR1I2 (0.35) | LPAR1LPAR3NR1H4GAANR1I2 | |
| SCHEMBL7689 | 0.78 | CYP1A2 (0.31) | CYP2C9TDP1 | |
| SCHEMBL1448 | 0.78 | BRD4 (0.35) | LPAR1LPAR3CYP2C9ALDH1A1EDNRB | |
| SCHEMBL7386 | 0.75 | SMN1; SMN2 (0.38) | LPAR1LPAR3NR1H4GAANR1I2 | |
| SCHEMBL2612 | 0.74 | LPAR1 (0.46) | LPAR1LPAR3NR1H4GAAABCC3 | |
| SCHEMBL1625 | 0.74 | AR (0.37) | LPAR1LPAR3NR1H4GAAABCC3 | |
| SCHEMBL1464 | 0.74 | GAA (0.38) | LPAR1LPAR3NR1H4GAAABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |