Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11409741 | 1.00 | LMNA (0.48) | LMNATSHRSMN1; SMN2CASP1SRD5A2 | |
| SCHEMBL11408875 | 0.87 | MEN1 (0.45) | TSHRSMN1; SMN2CASP1SRD5A2ALDH1A1 | |
| SCHEMBL11408874 | 0.87 | MEN1 (0.45) | TSHRSMN1; SMN2CASP1SRD5A2ALDH1A1 | |
| SCHEMBL11404916 | 0.83 | LMNA (0.50) | LMNATSHRSMN1; SMN2CASP1ALDH1A1 | |
| SCHEMBL11425756 | 0.80 | DHODH (0.50) | LMNATSHRSMN1; SMN2CASP1SRD5A2 | |
| SCHEMBL11425754 | 0.80 | DHODH (0.50) | LMNATSHRSMN1; SMN2CASP1SRD5A2 | |
| SCHEMBL11418731 | 0.78 | ALDH1A1 (0.47) | LMNATSHRSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL11418727 | 0.78 | ALDH1A1 (0.47) | LMNATSHRSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL11431151 | 0.77 | MEN1 (0.46) | LMNATSHRSRD5A2ALDH1A1TTR | |
| SCHEMBL11431148 | 0.77 | MEN1 (0.46) | LMNATSHRSRD5A2ALDH1A1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4200648-A | INFLAMMATION BY ADMINISTERING A BENZYLIDENEANILINE DERIVATIVE | WILLIAM H. RORER, INC. (US) | 1980-04-29 | — | — | US | disclosed |
| US-4198349-A | ANTIINFLAMMATORY, TOPICAL | WILLIAM H. RORER, INC. (US) | 1980-04-15 | — | — | US | disclosed |