Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 6/20 | 0.42 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | LIG1 | P18858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.41 |
| ▸ | MPI | P34949 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11410350 | 1.00 | MAPT (0.46) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL11418898 | 0.85 | POLB (0.51) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL10628465 | 0.85 | POLB (0.51) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL11415295 | 0.81 | CA2 (0.59) | MAPTKDM4EALDH1A1HPGDCA2 | |
| SCHEMBL11415299 | 0.81 | CA2 (0.59) | MAPTKDM4EALDH1A1HPGDCA2 | |
| SCHEMBL14337533 | 0.78 | CA2 (0.55) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL1238795 | 0.78 | CA2 (0.55) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL5084597 | 0.78 | MAPT (0.50) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL2322410 | 0.78 | CA2 (0.55) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL30373259 | 0.78 | CA2 (0.55) | MAPTLMNAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4235929-A | TOPICAL ADMINISTRATION OF ANTIINFLAMMATORY AGENT | WILLIAM H. RORER, INC. (US) | 1980-11-25 | — | — | US | disclosed |
| US-4198349-A | ANTIINFLAMMATORY, TOPICAL | WILLIAM H. RORER, INC. (US) | 1980-04-15 | — | — | US | disclosed |
| US-4176198-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1979-11-27 | — | — | US | disclosed |