Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11833431 | 0.92 | SIGMAR1 (0.33) | TSHRSMN1; SMN2SIGMAR1BACE1 | |
| SCHEMBL11848079 | 0.87 | SIGMAR1 (0.35) | TSHRKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL11274752 | 0.86 | TSHR (0.44) | TSHRPOLBHPGDALDH1A1MAPT | |
| SCHEMBL11137539 | 0.86 | ALDH1A1 (0.39) | TSHRPOLBHPGDALDH1A1MAPT | |
| SCHEMBL11412481 | 0.83 | HTT (0.50) | TSHRPOLBHPGDALDH1A1MAPT | |
| SCHEMBL11419376 | 0.83 | RAPGEF4 (0.45) | TSHRPOLBHPGDALDH1A1MAPT | |
| SCHEMBL11839280 | 0.81 | HTT (0.35) | TSHRPOLBHPGDALDH1A1MAPT | |
| SCHEMBL11841298 | 0.81 | HTT (0.35) | TSHRPOLBHPGDALDH1A1MAPT | |
| SCHEMBL11282636 | 0.81 | HTT (0.38) | TSHRPOLBHPGDALDH1A1MAPT | |
| SCHEMBL11838665 | 0.78 | CYP3A4 (0.31) | TSHRALDH1A1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4216230-A | Method for alleviating hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4216229-A | 1-AMIDINO-3-PHENYLUREAS | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-3959488-A | 1-Substituted biguanides for treating hyperacidity or ulceration | WILLIAM H. RORER, INC. (US) | 1976-05-25 | — | — | US | disclosed |