Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 3/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17807791 | 0.72 | CASR (0.45) | CASR | |
| SCHEMBL7688681 | 0.69 | POLB (0.42) | ADORA3NR1I2EGFRADRA2ATBXA2R | |
| SCHEMBL22419361 | 0.69 | CASR (0.44) | ADORA3NR1I2EGFRADRA2ATBXA2R | |
| SCHEMBL23531670 | 0.65 | ATAD2 (0.44) | ATAD2UHRF1TERTCYP3A4TSHR | |
| SCHEMBL29824722 | 0.65 | ATAD2 (0.44) | ATAD2UHRF1TERTCYP3A4TSHR | |
| SCHEMBL31716785 | 0.65 | TERT (0.40) | ATAD2SMN1; SMN2UHRF1TERTCLK4 | |
| SCHEMBL16477322 | 0.63 | ALDH1A1 (0.32) | SMN1; SMN2ADORA2B | |
| SCHEMBL31716739 | 0.62 | ATAD2 (0.42) | ATAD2CYP3A4TSHRMAPK1 | |
| SCHEMBL17807776 | 0.62 | CASR (0.36) | CASR | |
| SCHEMBL27229130 | 0.61 | BTK (0.37) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4224328-A | Methods with 1-substituted-4-aryl-quinazolin-2(1H)-ones and thiones and pyrido[2,3-d]pyrimidin-2-ones as platelet aggregation inhibitors | SANDOZ, INC. (US) | 1980-09-23 | — | — | US | disclosed |