Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11432617 | 0.86 | HTT (0.48) | POLBSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL28420264 | 0.84 | POLB (0.45) | POLBSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL11133278 | 0.83 | CA1 (0.54) | POLBSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL9313406 | 0.83 | POLB (0.56) | POLBSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL30827320 | 0.83 | CA1 (0.54) | POLBSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL11423764 | 0.83 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2ALDH1A1RECQLRAB9A | |
| SCHEMBL11419842 | 0.83 | KMT2A (0.51) | POLBSMN1; SMN2HTTLMNAMAPT | |
| SCHEMBL11419588 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1RECQLHTTPLK1 | |
| SCHEMBL11315297 | 0.81 | CYP1A2 (0.43) | POLBSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL11423498 | 0.81 | PKM (0.51) | POLBSMN1; SMN2ALDH1A1RECQLNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4183956-A | Method for treating gastrointestinal spasms, gastrointestinal hyperacidity and hypertensive disorders with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-01-15 | — | — | US | disclosed |