Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | CD40 | P25942 | 3/20 | 0.56 |
| ▸ | CD40LG | P29965 | 3/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.53 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.53 |
| ▸ | CASP6 | P55212 | 2/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11421997 | 0.90 | RAB9A (0.59) | NPC1MAPTRAB9ADUSP3PTPN5 | |
| SCHEMBL11437659 | 0.89 | MAPT (0.62) | NPC1MAPTRAB9ACD40CD40LG | |
| SCHEMBL11436835 | 0.84 | MAPT (0.60) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL11433792 | 0.84 | MAPT (0.53) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL11438050 | 0.84 | MAPT (0.62) | NPC1MAPTRAB9ACD40CD40LG | |
| SCHEMBL10651419 | 0.84 | CASP6 (0.65) | NPC1MAPTRAB9ADUSP3PTPN5 | |
| SCHEMBL10907852 | 0.84 | CASP6 (0.53) | NPC1RAB9ACD40CD40LGCASP6 | |
| SCHEMBL11339145 | 0.84 | TIMP3 (0.58) | MAPTRAB9ACASP6MEN1KMT2A | |
| SCHEMBL11434114 | 0.83 | APEX1 (0.60) | NPC1MAPTRAB9ACD40CD40LG | |
| SCHEMBL11500547 | 0.82 | CD40 (0.61) | NPC1MAPTRAB9ACD40CD40LG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4216166-A | Nitro precursors to amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |