Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | QPCT | Q16769 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11388731 | 0.81 | TBXAS1 (0.62) | SMN1; SMN2HTTL3MBTL1KDM4E | |
| SCHEMBL27285135 | 0.78 | NPC1 (0.60) | SMN1; SMN2CYP1A2CYP3A4CYP2D6MEN1 | |
| SCHEMBL13503153 | 0.77 | CYP1A2 (0.67) | SMN1; SMN2HTTL3MBTL1KDM4ECYP1A2 | |
| SCHEMBL1775043 | 0.75 | CYP1A2 (0.79) | SMN1; SMN2HTTL3MBTL1KDM4ECYP1A2 | |
| SCHEMBL3816499 | 0.75 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTALDH1A1MEN1KMT2A | |
| SCHEMBL10985519 | 0.75 | SMN1; SMN2 (0.83) | SMN1; SMN2HTTALDH1A1MEN1KMT2A | |
| SCHEMBL5050746 | 0.75 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTALDH1A1MEN1KMT2A | |
| SCHEMBL30499260 | 0.74 | HTT (0.60) | SMN1; SMN2HTTKDM4EALDH1A1MEN1 | |
| SCHEMBL10833281 | 0.74 | ALDH1A1 (0.87) | SMN1; SMN2HTTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL10833432 | 0.74 | L3MBTL1 (0.72) | SMN1; SMN2L3MBTL1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273782-A | FOR USE IN CARDIOVASCULAR DISORDERS AND COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1981-06-16 | — | — | US | disclosed |