Phosphine

Phosphine

SCHEMBL114295

IC(c1ccccc1)(c1ccccc1)c1ccccc1.P

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 4/20 0.45
ALDH1A1 P00352 3/20 0.45
TSHR P16473 2/20 0.45
MAPK1 P28482 1/20 0.39
CYP1A2 P05177 2/20 0.36
TAAR1 Q96RJ0 1/20 0.36
ALOX15 P16050 1/20 0.36
ESR1 P03372 2/20 0.35
ESR2 Q92731 2/20 0.35
PTPN1 P18031 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KIF11 P52732 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL874140 0.97 KCNN4 (0.47) KCNN4ALDH1A1TSHRMAPK1CYP1A2
Biphenyl SCHEMBL3341722 0.88 ALDH1A1 (0.53) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL31509718 0.85 KCNN4 (0.39) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL2261820 0.76 KCNN4 (0.47) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL1315561 0.76 KCNN4 (0.47) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL23157234 0.75 CA4 (0.54) KIF11
SCHEMBL18196315 0.75 CA4 (0.54) KIF11
SCHEMBL11089008 0.73 ALDH1A1 (0.45) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL2549759 0.73 KCNN4 (0.45) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL29161115 0.73 KCNN4 (0.45) KCNN4ALDH1A1TSHRMAPK1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9006447-B2 Method for preparing substituted isoxazoline compounds and their precursors 4-chloro, 4-bromo- or 4-iodobenzaldehyde oximes BASF SE (DE) 2015-04-14 US claimed
EP-2424862-B1 PROCESS FOR PREPARING SUBSTITUTED ISOXAZOLINE COMPOUNDS AND THEIR PRECURSORS BASF SE (DE) 2014-10-08 EP claimed
US-8853410-B2 Process for preparing substituted isoxazoline compounds and their precursors BASF SE (DE) 2014-10-07 US claimed
EP-2635552-A2 METHOD FOR PREPARING SUBSTITUTED ISOXAZOLINE COMPOUNDS AND THEIR PRECURSORS 4-CHLORO, 4-BROMO- OR 4-IODOBENZALDEHYDE OXIMES BASF SE (DE) 2013-09-11 EP claimed
US-20130225826-A1 Method for preparing substituted isoxazoline compounds and their precursors 4-chloro, 4-bromo- or 4-iodobenzaldehyde oximes BASF SE (DE) 2013-08-29 US claimed
WO-2012059441-A2 METHOD FOR PREPARING SUBSTITUTED ISOXAZOLINE COMPOUNDS AND THEIR PRECURSORS 4-CHLORO, 4-BROMO- OR 4-IODOBENZALDEHYDE OXIMES BASF SE (DE) 2012-05-10 WO claimed
US-20120059171-A1 Process for Preparing Substituted Isoxazoline Compounds and Their Precursors BASF SE (DE) 2012-03-08 US claimed
EP-2424862-A1 PROCESS FOR PREPARING SUBSTITUTED ISOXAZOLINE COMPOUNDS AND THEIR PRECURSORS BASF SE (DE) 2012-03-07 EP claimed
WO-2010125130-A1 PROCESS FOR PREPARING SUBSTITUTED ISOXAZOLINE COMPOUNDS AND THEIR PRECURSORS BASF SE (DE) 2010-11-04 WO claimed
US-4913843-A AIR DRYABLE COATING OF THERMOPARTICULATING COMPOUND AND RESIN CARRIER IN ORGANIC SOLVENT WESTINGHOUSE ELECTRIC CORP. (US) 1990-04-03 US claimed
CN-119518105-A Method for manufacturing lithium ion battery 三菱化学株式会社 2025-02-25 CN disclosed
CN-115697009-A Quantum dot light-emitting device and preparation method thereof 广东聚华印刷显示技术有限公司 2023-02-03 CN disclosed
CN-107573295-B Molecules and intermediates having pesticidal utility, compositions and methods relating thereto 美国陶氏益农公司 2020-12-15 CN disclosed
CN-109071485-B Process and system for recycling process water in the production of ethylene glycol 国际壳牌研究有限公司 2020-09-22 CN disclosed
CN-111518035-A Rosuvastatin tert-butylamine salt and preparation method thereof 安徽鼎旺医药有限公司 2020-08-11 CN disclosed
US-4913843-A AIR DRYABLE COATING OF THERMOPARTICULATING COMPOUND AND RESIN CARRIER IN ORGANIC SOLVENT WESTINGHOUSE ELECTRIC CORP. (US) 1990-04-03 US disclosed
US-4118406-A MULTISTEP, SODIUM OR POTASSIUM, HEXAALKYL PHOSPHORIC ACID TRIAMIDE, PHOSPHONIUM SALTS, ALDEHYDES HOECHST AKTIENGESELLSCHAFT (DE) 1978-10-03 US disclosed
US-4066605-A LUBRICATIVE, MOLYBDENUM DISULFIDE, CURABLE EPOXY RESIN MCBRIDE LA VAUGHN R 1978-01-03 US disclosed
US-4057593-A FROM PHOSPHONIUM SALT AND ALDEHYDE HOECHST AKTIENGESELLSCHAFT (DT) 1977-11-08 US disclosed
US-3950571-A MIXTURE OF POWDERED MOLYBDENUM DISULFIDE AND EPOXY RESIN MCBRIDE LA VAUGHN R 1976-04-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130225826-A1 Method for preparing substituted isoxazoline compounds and their precursors 4-chloro, 4-bromo- or 4-iodobenzaldehyde oximes CYP4X1, CYP4B1, AOX1 KCNN4 682/4885ALDH1A1 445/4885TSHR 1156/4885
US-20120059171-A1 Process for Preparing Substituted Isoxazoline Compounds and Their Precursors CYP4X1, CYP3A7, CYP1B1 KCNN4 2657/4885ALDH1A1 202/4885TSHR 1220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.