Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | DUT | P33316 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 15/20 | 0.34 |
| ▸ | CA2 | P00918 | 15/20 | 0.34 |
| ▸ | CA9 | Q16790 | 14/20 | 0.34 |
| ▸ | CA12 | O43570 | 5/20 | 0.34 |
| ▸ | CA7 | P43166 | 5/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.34 |
| ▸ | CA3 | P07451 | 4/20 | 0.34 |
| ▸ | CA4 | P22748 | 4/20 | 0.34 |
| ▸ | CA6 | P23280 | 4/20 | 0.34 |
| ▸ | CA5A | P35218 | 4/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235404 | 1.00 | TSHR (0.56) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL10943473 | 1.00 | TSHR (0.56) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL10990981 | 1.00 | TSHR (0.56) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL10949282 | 0.98 | KDM4E (0.58) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL10982965 | 0.94 | KDM4E (0.52) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL1744548 | 0.93 | KDM4E (0.48) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL1744584 | 0.90 | KDM4E (0.44) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL4188554 | 0.86 | USP2 (0.44) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL14245094 | 0.82 | DUT (0.42) | DUT | |
| SCHEMBL9007756 | 0.82 | DUT (0.42) | DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459560-B1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | MERCK SHARP & DOHME (NL) | 2015-08-19 | — | — | EP | disclosed |
| EP-2459560-B1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | MERCK SHARP & DOHME (NL) | 2015-08-19 | — | — | EP | disclosed |
| US-8431564-B2 | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines | MERCK SHARP & DOHME B.V. (NL) | 2013-04-30 | — | — | US | disclosed |
| US-8431564-B2 | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines | MERCK SHARP & DOHME B.V. (NL) | 2013-04-30 | — | — | US | disclosed |
| US-8431564-B2 | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines | MERCK SHARP & DOHME B.V. (NL) | 2013-04-30 | — | — | US | disclosed |
| EP-2459560-A1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | MSD Oss B.V. (NL) | 2012-06-06 | — | — | EP | disclosed |
| US-20110028450-A1 | Ring-annulated dihydropyrrolo[2,1-alpha]isoquinolines | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| US-20110028450-A1 | Ring-annulated dihydropyrrolo[2,1-alpha]isoquinolines | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| WO-2011012600-A1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2011-02-03 | — | — | WO | disclosed |
| EP-0140307-A2 | 7-Oxabicycloheptane ethers | E.R. Squibb & Sons, Inc. (US) | 1985-05-08 | — | — | EP | disclosed |
| US-4513103-A | 7-Oxabicycloheptane ethers useful in the treatment of thrombolytic disease | E. R. SQUIBB & SONS, INC. (US) | 1985-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028450-A1 | Ring-annulated dihydropyrrolo[2,1-alpha]isoquinolines | CATSPER1, QDPR, NASP | TSHR 2975/4885KDM4E 2195/4885USP2 4420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.