Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.55 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11423374 | 0.89 | NPC1 (0.60) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11442222 | 0.86 | RAB9A (0.59) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11431680 | 0.84 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11442387 | 0.82 | MEN1 (0.53) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11426750 | 0.82 | MEN1 (0.60) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11431004 | 0.81 | HDAC1 (0.53) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11350051 | 0.81 | KMT2A (0.53) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL10907651 | 0.81 | NPC1 (0.45) | NPC1RAB9AKMT2AMEN1TDP1 | |
| SCHEMBL11760548 | 0.81 | KMT2A (0.56) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11429118 | 0.80 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4216166-A | Nitro precursors to amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |