Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11436258 | 0.88 | OPRM1 (0.41) | OPRM1SIGMAR1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11437818 | 0.83 | OPRM1 (0.45) | OPRM1SIGMAR1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11456889 | 0.83 | OPRM1 (0.45) | OPRM1SIGMAR1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11437893 | 0.83 | OPRM1 (0.45) | OPRM1SIGMAR1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11434872 | 0.77 | CHRM2 (0.37) | OPRM1OPRD1OPRK1CHRM1CHRM3 | |
| SCHEMBL11334216 | 0.75 | OPRM1 (0.44) | OPRM1SIGMAR1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11450496 | 0.75 | ALDH1A1 (0.39) | OPRM1SIGMAR1OPRD1OPRK1CHRM3 | |
| SCHEMBL11339568 | 0.75 | OPRM1 (0.44) | OPRM1SIGMAR1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11436715 | 0.73 | OPRM1 (0.55) | OPRM1SIGMAR1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11465430 | 0.72 | KDM4E (0.35) | OPRM1SIGMAR1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4217362-A | Anilide derivatives as antidepressants | THE UPJOHN COMPANY (US) | 1980-08-12 | — | — | US | disclosed |
| US-4212888-A | Anilide derivatives as antidepressants | THE UPJOHN COMPANY (US) | 1980-07-15 | — | — | US | disclosed |
| US-4128663-A | Anilide derivatives as antidepressants | THE UPJOHN COMPANY (US) | 1978-12-05 | — | — | US | disclosed |