Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641259 | 0.98 | CA2 (0.39) | CA2TP53TAAR1SMN1; SMN2LMNA | |
| Iodide SCHEMBL4336770 | 0.96 | SMN1; SMN2 (0.39) | CA2TP53TAAR1SMN1; SMN2LMNA | |
| Bromide SCHEMBL10844297 | 0.83 | CA2 (0.35) | CA2TP53TAAR1SMN1; SMN2LMNA | |
| Bromide SCHEMBL8658730 | 0.77 | SMN1; SMN2 (0.44) | CA2TP53SMN1; SMN2LMNAKDM4E | |
| Bromide SCHEMBL10858949 | 0.77 | SMN1; SMN2 (0.44) | CA2TP53SMN1; SMN2LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL11428178 | 0.76 | LPL (0.35) | CA2TP53TAAR1SMN1; SMN2CYP2A6 | |
| SCHEMBL8723606 | 0.76 | KDM4E (0.36) | CA2TP53TAAR1SMN1; SMN2LMNA | |
| Bromide SCHEMBL11581070 | 0.76 | TP53 (0.47) | CA2TP53TAAR1SMN1; SMN2LMNA | |
| SCHEMBL1105765 | 0.75 | LMNA (0.43) | SMN1; SMN2LMNAKDM4EMEN1APOBEC3A | |
| Hydrochloric Acid SCHEMBL11442433 | 0.74 | HTT (0.42) | CA2TP53SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4228230-A | Ultrasonic imaging of internally fogged silver halide elements | EASTMAN KODAK COMPANY (US) | 1980-10-14 | — | — | US | disclosed |