Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7765557 | 1.00 | PDE4B (0.65) | PDE4BPDE4DKDM4EALDH1A1AOX1 | |
| SCHEMBL11435807 | 0.87 | PDE4B (0.77) | PDE4BPDE4DKDM4EPTGER3MEN1 | |
| SCHEMBL8486179 | 0.81 | PDE4B (0.67) | PDE4BPDE4DKDM4EALDH1A1PTGER3 | |
| SCHEMBL7763958 | 0.81 | PDE4B (0.82) | PDE4BPDE4DALDH1A1HPGDMAPT | |
| SCHEMBL7764115 | 0.81 | PDE4B (0.82) | PDE4BPDE4DALDH1A1HPGDMAPT | |
| SCHEMBL7760278 | 0.81 | PDE4B (0.82) | PDE4BPDE4DALDH1A1HPGDMAPT | |
| SCHEMBL7763939 | 0.80 | PDE4B (0.64) | PDE4BPDE4DKDM4EPTGER3MEN1 | |
| Daxalipram SCHEMBL450824 | 0.79 | PDE4B (1.00) | PDE4BPDE4DKDM4EALDH1A1CYP1A2 | |
| SCHEMBL7764133 | 0.79 | PDE4B (0.75) | PDE4BPDE4DKDM4EALDH1A1PTGER3 | |
| SCHEMBL7763217 | 0.79 | PDE4B (0.75) | PDE4BPDE4DKDM4EALDH1A1PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859766-B1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AG (DE) | 2001-05-16 | — | — | EP | claimed |
| EP-0859766-B1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AG (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6025376-A | INHIBITORS OF TUMOR NECROSIS FACTOR, TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |