Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | CD40 | P25942 | 2/20 | 0.44 |
| ▸ | CD40LG | P29965 | 2/20 | 0.44 |
| ▸ | TIMP3 | P35625 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11424495 | 0.94 | APEX1 (0.49) | APEX1CD40CD40LGTIMP3MEN1 | |
| SCHEMBL11437636 | 0.84 | CD40 (0.57) | APEX1CD40CD40LGTIMP3MEN1 | |
| SCHEMBL11513442 | 0.84 | CD40 (0.57) | APEX1CD40CD40LGTIMP3MEN1 | |
| Lindane SCHEMBL11427662 | 0.84 | APEX1 (0.48) | APEX1TIMP3MEN1KMT2APOLB | |
| SCHEMBL11473094 | 0.84 | APEX1 (0.54) | APEX1CD40CD40LGTIMP3MEN1 | |
| SCHEMBL11597984 | 0.83 | APEX1 (0.65) | APEX1TIMP3MEN1KMT2APOLB | |
| SCHEMBL30478480 | 0.81 | CD40 (0.59) | APEX1CD40CD40LGTIMP3MEN1 | |
| SCHEMBL11468420 | 0.80 | MEN1 (0.55) | APEX1CD40CD40LGTIMP3MEN1 | |
| SCHEMBL11432542 | 0.78 | APEX1 (0.44) | APEX1CD40CD40LGTIMP3MEN1 | |
| SCHEMBL11442053 | 0.78 | APEX1 (0.44) | APEX1CD40CD40LGTIMP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4229371-A | INHIBITORS OF THE COMPLEMENT SYSTEM, IMMUNOLOGY | AMERICAN CYANAMID COMPANY (US) | 1980-10-21 | — | — | US | disclosed |
| US-4132730-A | COMPLEMENT INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1979-01-02 | — | — | US | disclosed |