Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LDHA | P00338 | 2/20 | 0.38 |
| ▸ | LDHB | P07195 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL1613092 | 0.88 | MAPT (0.50) | MAPTHIF1APDE4AKDRKMT2A | |
| Piperazine SCHEMBL4778411 | 0.88 | MAPT (0.50) | MAPTHIF1APDE4AKDRKMT2A | |
| Pyrrolidine SCHEMBL4076061 | 0.86 | ALDH1A1 (0.50) | MAPTKMT2AKDM4ELDHALDHB | |
| Piperazine SCHEMBL30586091 | 0.85 | ACHE (0.54) | MAPTHIF1APDE4AKDRKMT2A | |
| Piperazine SCHEMBL6371041 | 0.85 | LMNA (0.46) | MAPTHIF1APDE4AKDRKMT2A | |
| Piperazine SCHEMBL250578 | 0.85 | ACHE (0.54) | MAPTHIF1APDE4AKDRKMT2A | |
| Piperazine SCHEMBL28250842 | 0.85 | MAPT (0.46) | MAPTHIF1APDE4AKDRKMT2A | |
| Urea SCHEMBL1769303 | 0.84 | — | — | |
| Azepane SCHEMBL11282804 | 0.83 | ALDH1A1 (0.56) | MAPTKMT2AKDM4ELDHALDHB | |
| Piperidine SCHEMBL11283067 | 0.83 | ALDH1A1 (0.56) | MAPTKMT2AKDM4ELDHALDHB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4223105-A | POLYAMIDES AND POLYESTERS | IGONIN VADIM B | 1980-09-16 | — | — | US | disclosed |