Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 4/20 | 0.42 |
| ▸ | CES1 | P23141 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11663344 | 0.96 | CYP1A2 (0.50) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 | |
| Acetic Acid SCHEMBL328882 | 0.94 | TSHR (0.48) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 | |
| Oxalic Acid SCHEMBL10577823 | 0.94 | CYP1A2 (0.48) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 | |
| Acetic Acid SCHEMBL133341 | 0.94 | TSHR (0.48) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 | |
| Acetic Acid SCHEMBL10484555 | 0.92 | CYP1A2 (0.47) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 | |
| Propionic Acid SCHEMBL1399930 | 0.92 | CYP1A2 (0.47) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 | |
| Acetic Acid SCHEMBL9467718 | 0.92 | TSHR (0.47) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 | |
| Acetic Acid SCHEMBL27993794 | 0.92 | TSHR (0.47) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 | |
| Acetic Acid SCHEMBL328881 | 0.92 | TSHR (0.47) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 | |
| Acetic Acid SCHEMBL10580400 | 0.90 | TSHR (0.46) | CYP1A2TSHRALDH1A1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4354015-A | HIGH MOLECULAR WEIGHT LINEAR EPOXY RESINS | THE DOW CHEMICAL COMPANY (US) | 1982-10-12 | — | — | US | claimed |
| US-12624156-B2 | Processes for forming epoxy resin compositions and separation processes | Westlake Epoxy Inc. (US) | 2026-05-12 | — | — | US | disclosed |
| EP-4688949-A1 | PROCESSES FOR FORMING EPOXY RESIN COMPOSITIONS AND SEPARATION PROCESSES | Westlake Epoxy Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| EP-4688950-A1 | PROCESSES FOR FORMING EPOXY RESIN COMPOSITIONS AND SEPARATION PROCESSES | Westlake Epoxy Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| US-20240336723-A1 | PROCESSES FOR FORMING EPOXY RESIN COMPOSITIONS AND SEPARATION PROCESSES | Westlake Epoxy Inc. | 2024-10-10 | — | — | US | disclosed |
| WO-2024211145-A1 | PROCESSES FOR FORMING EPOXY RESIN COMPOSITIONS AND SEPARATION PROCESSES | Westlake Epoxy Inc. (US) | 2024-10-10 | — | — | WO | disclosed |
| WO-2024211144-A1 | PROCESSES FOR FORMING EPOXY RESIN COMPOSITIONS AND SEPARATION PROCESSES | Westlake Epoxy Inc. (US) | 2024-10-10 | — | — | WO | disclosed |
| US-20240336722-A1 | PROCESSES FOR FORMING EPOXY RESIN COMPOSITIONS AND SEPARATION PROCESSES | Westlake Epoxy Inc. | 2024-10-10 | — | — | US | disclosed |
| EP-2794712-B1 | EPOXY RESIN PRODUCTION | BLUE CUBE IP LLC (US) | 2018-04-18 | — | — | EP | disclosed |
| CN-104011106-B | The production of epoxy resin | 蓝立方知识产权有限责任公司 | 2017-09-12 | — | — | CN | disclosed |
| US-4481347-A | ADDUCTS CURABLE TO POLYEPOXIDES | THE DOW CHEMICAL COMPANY (US) | 1984-11-06 | — | — | US | disclosed |
| US-4474943-A | Phosphoramide epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0079947-A4 | Process for the preparation of stable precatalyzed epoxy resin compositions. | DOW CHEMICAL CO (US) | 1983-09-20 | — | — | EP | disclosed |
| US-4404381-A | Novel 3,5-diketo-piperazinyl compounds containing epoxide substituted imides | THE DOW CHEMICAL COMPANY (US) | 1983-09-13 | — | — | US | disclosed |
| EP-0079947-A1 | Process for the preparation of stable precatalyzed epoxy resin compositions. | DOW CHEMICAL CO (US) | 1983-06-01 | — | — | EP | disclosed |
| US-4366295-A | PHOSPHONIUM SALT | THE DOW CHEMICAL COMPANY (US) | 1982-12-28 | — | — | US | disclosed |
| WO-1982004257-A1 | STABLE PRECATALYZED EPOXY RESIN COMPOSITIONS | DOW CHEMICAL CO (US) | 1982-12-09 | — | — | WO | disclosed |
| US-4354015-A | HIGH MOLECULAR WEIGHT LINEAR EPOXY RESINS | THE DOW CHEMICAL COMPANY (US) | 1982-10-12 | — | — | US | disclosed |
| US-4313886-A | USING AMMONIUM, PHOSPHONIUM OR SULFONIUM CATALYST | THE DOW CHEMICAL COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| EP-0028810-A2 | Solvent-free process for preparing liquid epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1981-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240336722-A1 | PROCESSES FOR FORMING EPOXY RESIN COMPOSITIONS AND SEPARATION PROCESSES | EPHX2, EPHX1, HDHD5 | CYP1A2 567/4885TSHR 4429/4885ALDH1A1 181/4885 |
| US-12624156-B2 | Processes for forming epoxy resin compositions and separation processes | EPHX1, EPHX2, RER1 | CYP1A2 548/4885TSHR 2648/4885ALDH1A1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.