SCHEMBL11444451

SCHEMBL11444451

Nc1c(-c2ccccc2)n[nH]c(=O)c1Br

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.61
ATM Q13315 1/20 0.61
KDM4E B2RXH2 5/20 0.56
ALDH1A1 P00352 5/20 0.56
GAA P10253 2/20 0.56
HSD17B10 Q99714 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
NPC1 O15118 2/20 0.56
HPGD P15428 2/20 0.56
RAB9A P51151 2/20 0.56
CDK5 Q00535 2/20 0.54
CLK4 Q9HAZ1 2/20 0.54
CDK8 P49336 1/20 0.54
XDH P47989 1/20 0.53
PKM P14618 1/20 0.47
MAPT P10636 2/20 0.46
POLB P06746 1/20 0.46
ALOX15 P16050 1/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2650149 0.86 CLK4 (0.57) NPSR1ATMKDM4EALDH1A1GAA
Hydrochloric Acid SCHEMBL2650936 0.82 NPSR1 (0.65) NPSR1ATMKDM4EALDH1A1GAA
SCHEMBL7621639 0.79 NPSR1 (0.61) NPSR1ATMKDM4EALDH1A1GAA
SCHEMBL7617054 0.76 CDK8 (0.57) NPSR1ATMKDM4EALDH1A1GAA
SCHEMBL581143 0.76 NPSR1 (1.00) NPSR1ATMKDM4EALDH1A1GAA
SCHEMBL29870198 0.76 NPSR1 (1.00) NPSR1ATMKDM4EALDH1A1GAA
SCHEMBL4059335 0.75 CDK8 (0.60) NPSR1ATMKDM4EALDH1A1GAA
SCHEMBL4057416 0.74 ALDH1A1 (0.53) NPSR1ATMKDM4EALDH1A1GAA
SCHEMBL5236193 0.74 ALDH1A1 (0.68) NPSR1ATMKDM4EALDH1A1GAA
SCHEMBL31014281 0.73 NPSR1 (0.67) NPSR1ATMKDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0017001-A1 Herbicides in the form of an aqueous suspension containing a pyridazone and a thiolcarbamate, a chloroacetanilide or a dinitroaniline, and a method for their preparation and its use in combating undesired plant growth BASF Aktiengesellschaft (DE) 1980-10-15 EP claimed
EP-0005516-A2 Substituted pyridazinons, process for their preparation and their use as herbicides BASF Aktiengesellschaft (DE) 1979-11-28 EP disclosed