Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 7/20 | 0.54 |
| ▸ | HTR7 | P34969 | 6/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447942 | 0.94 | HTR7 (0.60) | CACNA1GPOLBHTR1AHTR7PKM | |
| SCHEMBL11446706 | 0.91 | HTR1A (0.57) | CACNA1GPOLBHTR1AHTR7PKM | |
| SCHEMBL11447099 | 0.88 | HTR7 (0.52) | CACNA1GPOLBHTR1AHTR7MAPT | |
| SCHEMBL11457535 | 0.88 | HTR7 (0.59) | HTR1AHTR7MAPTKMT2ADRD2 | |
| Hydrochloric Acid SCHEMBL11447560 | 0.87 | HTR7 (0.51) | CACNA1GPOLBHTR1AHTR7MAPT | |
| SCHEMBL11456938 | 0.87 | HTR1A (0.71) | CACNA1GPOLBHTR1AHTR7PKM | |
| SCHEMBL11454634 | 0.87 | HSD17B10 (0.54) | POLBHTR1AHTR7KMT2ADRD2 | |
| SCHEMBL11456961 | 0.86 | MAPT (0.56) | HTR1AHTR7MAPTKMT2ADRD2 | |
| SCHEMBL11448262 | 0.86 | HTR1A (0.58) | POLBHTR1AHTR7KMT2ADRD2 | |
| Hydrochloric Acid SCHEMBL11500448 | 0.85 | HTR1A (0.57) | POLBHTR1AHTR7KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |