Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446043 | 0.94 | HTR7 (0.62) | HTR7HTR1ADRD2DRD3 | |
| SCHEMBL11446863 | 0.91 | HTR7 (0.59) | HTR7HTR1AADRB2ADRB1ADRB3 | |
| SCHEMBL11466045 | 0.91 | HTR7 (0.61) | HTR7HTR1AKMT2ASMN1; SMN2DRD4 | |
| SCHEMBL11447099 | 0.89 | HTR7 (0.52) | HTR7HTR1AKMT2ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL11447560 | 0.88 | HTR7 (0.51) | HTR7HTR1AADRB2ADRB1ADRB3 | |
| SCHEMBL11454634 | 0.88 | HSD17B10 (0.54) | HTR7HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL11446236 | 0.88 | CACNA1G (0.55) | HTR7HTR1AKMT2ASMN1; SMN2MAPT | |
| SCHEMBL11455011 | 0.87 | DRD4 (0.58) | HTR7HTR1AADRB1DRD4MAPT | |
| SCHEMBL11448262 | 0.87 | HTR1A (0.58) | HTR7HTR1AKMT2ASMN1; SMN2DRD2 | |
| SCHEMBL11446743 | 0.87 | HTR7 (0.57) | HTR7HTR1ADRD4MAPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |