Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11455011 | 0.95 | DRD4 (0.58) | HTR1AHTR7GFERDRD4MAPT | |
| SCHEMBL11446907 | 0.92 | GFER (0.60) | HTR1AHTR7KDM4EALDH1A1GFER | |
| SCHEMBL11498175 | 0.89 | GFER (0.62) | HTR1AHTR7KDM4EALDH1A1GFER | |
| SCHEMBL11454249 | 0.88 | HTR1A (0.70) | HTR1AHTR7HTR2A | |
| SCHEMBL11465175 | 0.88 | HTR7 (0.60) | HTR1AHTR7GFERDRD4LMNA | |
| SCHEMBL11446043 | 0.87 | HTR7 (0.62) | HTR1AHTR7GFERLMNADRD2 | |
| SCHEMBL11446001 | 0.87 | GFER (0.61) | HTR1AHTR7GFERDRD4MAPT | |
| SCHEMBL11465416 | 0.86 | DRD4 (0.60) | HTR1AHTR7KDM4EALDH1A1GFER | |
| SCHEMBL11447385 | 0.86 | HTR7 (0.61) | HTR1AHTR7DRD2HTR2A | |
| SCHEMBL11447942 | 0.85 | HTR7 (0.60) | HTR1AHTR7DRD4MAPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |