Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446702 | 0.95 | HTR1A (0.67) | HTR1AKCNH2HTR7HTR2ADRD3 | |
| SCHEMBL11498175 | 0.91 | GFER (0.62) | HTR1AHTR7HTR2A | |
| SCHEMBL11454884 | 0.89 | HTR1A (0.59) | HTR1AKCNH2HTR7HTR2ADRD3 | |
| SCHEMBL11446577 | 0.89 | HTR1A (0.61) | HTR1AHTR7HTR2ACACNA1G | |
| SCHEMBL11446907 | 0.88 | GFER (0.60) | HTR1AHTR7HTR2A | |
| SCHEMBL11446412 | 0.88 | HTR1A (0.59) | HTR1AHTR7HTR2A | |
| SCHEMBL11446583 | 0.88 | HTR7 (0.63) | HTR1AHTR7HTR2ADRD3CACNA1G | |
| SCHEMBL11454722 | 0.88 | HTR7 (0.74) | HTR1AKCNH2HTR7HTR2ADRD3 | |
| SCHEMBL11446686 | 0.87 | HTR7 (0.64) | HTR1AKCNH2HTR7HTR2ADRD3 | |
| SCHEMBL11447052 | 0.84 | GFER (0.56) | HTR1AHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |