Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11454667 | 0.94 | HTR7 (0.59) | DRD3DRD2HTR7MAPTPOLB | |
| SCHEMBL11456920 | 0.86 | HTR7 (0.59) | DRD3DRD2HTR7MAPTPOLB | |
| SCHEMBL11457088 | 0.85 | HTR7 (0.52) | DRD3DRD2HTR7MAPTMEN1 | |
| SCHEMBL11446863 | 0.85 | HTR7 (0.59) | HTR7MAPTMEN1TSHRKMT2A | |
| SCHEMBL11446706 | 0.84 | HTR1A (0.57) | DRD2HTR7MAPTPOLBKMT2A | |
| SCHEMBL11446419 | 0.84 | HSD17B10 (0.54) | DRD3DRD2HTR7POLBMEN1 | |
| SCHEMBL11448262 | 0.83 | HTR1A (0.58) | DRD3DRD2HTR7POLBMEN1 | |
| Hydrochloric Acid SCHEMBL11500448 | 0.82 | HTR1A (0.57) | DRD3DRD2HTR7POLBMEN1 | |
| SCHEMBL11446001 | 0.81 | GFER (0.61) | DRD3DRD2HTR7MAPTPOLB | |
| SCHEMBL11446596 | 0.81 | MAPT (0.49) | DRD2MAPTPOLBMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |