Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11498175 | 0.94 | GFER (0.62) | GFERHTR1AHTR2ADRD4KDM4E | |
| SCHEMBL11446702 | 0.89 | HTR1A (0.67) | HTR1AMAPTHTR2ADRD4DRD2 | |
| SCHEMBL11465074 | 0.88 | HTR1A (0.52) | GFERHTR1AMAPTKMT2AMEN1 | |
| SCHEMBL11448262 | 0.87 | HTR1A (0.58) | GFERHTR1AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11455011 | 0.87 | DRD4 (0.58) | GFERHTR1AMAPTHTR2ADRD4 | |
| SCHEMBL11446001 | 0.87 | GFER (0.61) | GFERHTR1AMAPTKMT2AMEN1 | |
| SCHEMBL11447026 | 0.86 | HTR7 (0.49) | GFERHTR1AMAPTKMT2AMEN1 | |
| SCHEMBL11456749 | 0.86 | HTR7 (0.52) | GFERHTR1AMAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11500448 | 0.86 | HTR1A (0.57) | GFERHTR1AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11456961 | 0.85 | MAPT (0.56) | HTR1AMAPTKMT2AMEN1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |