Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446335 | 0.93 | HTR7 (0.53) | HTR1AHTR7GFERSLC6A4SLC6A2 | |
| SCHEMBL11448262 | 0.90 | HTR1A (0.58) | HTR1AHTR7POLBGFERDRD2 | |
| SCHEMBL11447026 | 0.89 | HTR7 (0.49) | HTR1AHTR7POLBGFERMAPT | |
| SCHEMBL11456749 | 0.89 | HTR7 (0.52) | HTR1AHTR7POLBGFERMAPT | |
| Hydrochloric Acid SCHEMBL11500448 | 0.89 | HTR1A (0.57) | HTR1AHTR7POLBGFERDRD2 | |
| SCHEMBL11456961 | 0.88 | MAPT (0.56) | HTR1AHTR7MAPTNPSR1DRD2 | |
| SCHEMBL11447052 | 0.88 | GFER (0.56) | HTR1AGFERMAPTDRD2DRD3 | |
| SCHEMBL11447580 | 0.88 | HTR1A (0.56) | HTR1AHTR7DRD2DRD3MEN1 | |
| SCHEMBL11454634 | 0.86 | HSD17B10 (0.54) | HTR1AHTR7POLBGFERDRD2 | |
| SCHEMBL11446419 | 0.86 | HSD17B10 (0.54) | HTR1AHTR7POLBGFERDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |