Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448363 | 0.92 | MEN1 (0.48) | GFERDRD2HTR2AHRH1CCR3 | |
| SCHEMBL11447265 | 0.88 | HTR1A (0.54) | GFERMEN1KMT2AHTR1AGAA | |
| SCHEMBL11446084 | 0.88 | KMT2A (0.53) | HTR2ACCR3MEN1KMT2APOLB | |
| SCHEMBL11448296 | 0.87 | DRD2 (0.45) | DRD2HTR2AHRH1ADRA1DADRA1A | |
| SCHEMBL11456862 | 0.87 | DRD2 (0.45) | DRD2HTR2AHRH1ADRA1DADRA1A | |
| SCHEMBL11457257 | 0.87 | DRD2 (0.45) | DRD2HTR2AHRH1CCR3ADRA1D | |
| SCHEMBL11446922 | 0.86 | HTR2A (0.49) | GFERDRD2HTR2AHRH1ADRA1D | |
| SCHEMBL11446395 | 0.85 | DRD2 (0.49) | GFERDRD2HTR2AHRH1ADRA1D | |
| Hydrochloric Acid SCHEMBL11446447 | 0.84 | DRD2 (0.48) | GFERDRD2HTR2AHRH1ADRA1D | |
| SCHEMBL11446596 | 0.83 | MAPT (0.49) | DRD2HTR2AHRH1CCR3ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |