Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11457434 | 0.87 | POLB (0.56) | HTR7HTR1ADRD2KMT2ASMN1; SMN2 | |
| SCHEMBL11456652 | 0.86 | KMT2A (0.56) | HTR7HTR1ADRD2KMT2ASMN1; SMN2 | |
| SCHEMBL11448262 | 0.84 | HTR1A (0.58) | HTR7HTR1ADRD2KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11500448 | 0.83 | HTR1A (0.57) | HTR7HTR1ADRD2KMT2ASMN1; SMN2 | |
| SCHEMBL11447935 | 0.83 | POLB (0.60) | HTR7DRD2KMT2ASMN1; SMN2TSHR | |
| Phosphoric Acid SCHEMBL11448388 | 0.82 | HTR1A (0.54) | HTR7HTR1AKMT2ASMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL11446653 | 0.82 | POLB (0.61) | HTR7DRD2KMT2ASMN1; SMN2TSHR | |
| SCHEMBL11465707 | 0.81 | ALDH1A1 (0.55) | HTR7HTR1ADRD2KMT2ASMN1; SMN2 | |
| SCHEMBL11456795 | 0.81 | POLB (0.52) | HTR7DRD2KMT2ASMN1; SMN2TSHR | |
| SCHEMBL11447021 | 0.80 | ALDH1A1 (0.53) | HTR7HTR1ADRD2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |