Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 6/20 | 0.47 |
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11457761 | 0.98 | HTR2C (0.49) | HTR2CBRD4ATAD2CYP1A2MEN1 | |
| SCHEMBL1842397 | 0.79 | RAPGEF4 (0.46) | HTR2CBRD4ATAD2CYP1A2MEN1 | |
| SCHEMBL82566 | 0.79 | BRD4 (0.55) | HTR2CBRD4ATAD2CYP1A2MEN1 | |
| SCHEMBL22429117 | 0.79 | ALOX12 (0.57) | HSD17B10ALOX12EPHX1 | |
| SCHEMBL82901 | 0.78 | BRD4 (0.54) | HTR2CBRD4ATAD2CYP1A2MEN1 | |
| Hydrochloric Acid SCHEMBL70439 | 0.77 | HTR2C (0.54) | HTR2CBRD4ATAD2CYP1A2MEN1 | |
| Hydrochloric Acid SCHEMBL68445 | 0.76 | BRD4 (0.52) | HTR2CBRD4ATAD2CYP1A2MEN1 | |
| SCHEMBL11455156 | 0.74 | POLB (0.50) | HTR2CBRD4ATAD2KDM1AALOX12 | |
| SCHEMBL23360617 | 0.73 | ALDH1A1 (0.47) | BRD4ATAD2CYP1A2MEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL23360416 | 0.72 | ALDH1A1 (0.46) | BRD4ATAD2CYP1A2MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225606-A | ANTIARRHYTHEMIA AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-09-30 | — | — | US | disclosed |
| US-4208418-A | ANTIARRHYTHMIA | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-06-17 | — | — | US | disclosed |
| US-4198411-A | ANTIARRHYTHMIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-04-15 | — | — | US | disclosed |
| US-4197303-A | ANTIARRHYTHMIA AGENTS, ALKOXYCARBONYL ON 4-POSITION OF PIPERIDINE | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-04-08 | — | — | US | disclosed |
| US-4197304-A | ANTIARRHYTHMIA AGENTS, N-PYRIDINYL-N-(4-ALKYLPIPERIDINYL)THIENYLACETAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-04-08 | — | — | US | disclosed |
| US-4196210-A | ANTIARRHYTHMIA AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-04-01 | — | — | US | disclosed |
| US-4157393-A | ANTIARRHYTHMIA AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-06-05 | — | — | US | disclosed |
| US-4151286-A | ANTIARRHYTHMIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-04-24 | — | — | US | disclosed |
| US-4126689-A | ANTIARRHYTHMIA | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-11-21 | — | — | US | disclosed |