Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11341263 | 0.96 | SIGMAR1 (0.55) | SIGMAR1KCNH2HRH3CHRNA7OPRM1 | |
| SCHEMBL11457121 | 0.89 | SIGMAR1 (0.55) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11454746 | 0.89 | SIGMAR1 (0.51) | SIGMAR1OPRK1 | |
| SCHEMBL11338303 | 0.86 | SIGMAR1 (0.57) | SIGMAR1CHRNA7OPRM1OPRK1 | |
| SCHEMBL11339650 | 0.85 | SIGMAR1 (0.53) | SIGMAR1OPRK1 | |
| SCHEMBL11446906 | 0.81 | SIGMAR1 (0.39) | SIGMAR1CHRM2CHRM3KCNH2HRH3 | |
| SCHEMBL11341260 | 0.81 | SIGMAR1 (0.43) | SIGMAR1CHRM2CHRM3OPRM1OPRK1 | |
| SCHEMBL11457074 | 0.81 | SIGMAR1 (0.42) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11446429 | 0.79 | SIGMAR1 (0.51) | SIGMAR1OPRK1 | |
| SCHEMBL11454754 | 0.78 | SIGMAR1 (0.53) | SIGMAR1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4204003-A | N-(2-Aminocyclopentyl)-N-alkanoylanilides as CNS anti-depressants | THE UPJOHN COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| US-4159340-A | N-(2-Aminocyclopentyl)-N-acylanilides as CNS anti-depressants | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4157398-A | N-(2-Aminocyclopentyl)acylanilides and treating depression | THE UPJOHN COMPANY (US) | 1979-06-05 | — | — | US | disclosed |
| US-4156733-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-05-29 | — | — | US | disclosed |
| US-4156015-A | N-(2-Aminocyclopentyl)acylanilides and treating depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |
| US-4148913-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-04-10 | — | — | US | disclosed |