Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11457121 | 0.96 | SIGMAR1 (0.55) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11341263 | 0.89 | SIGMAR1 (0.55) | SIGMAR1OPRM1OPRK1CHRNA7 | |
| SCHEMBL11447938 | 0.86 | SIGMAR1 (0.53) | SIGMAR1OPRM1OPRK1CHRNA7 | |
| SCHEMBL11348032 | 0.79 | SIGMAR1 (0.59) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11339650 | 0.79 | SIGMAR1 (0.53) | SIGMAR1OPRK1 | |
| SCHEMBL11338301 | 0.78 | SIGMAR1 (0.45) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11344642 | 0.78 | SIGMAR1 (0.55) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11335003 | 0.78 | SIGMAR1 (0.55) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11338319 | 0.78 | SIGMAR1 (0.44) | SIGMAR1OPRM1OPRK1 | |
| SCHEMBL11343008 | 0.76 | SIGMAR1 (0.53) | SIGMAR1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE30837-E | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | disclosed |
| US-4199589-A | N-(2-Aminocycloheptyl)acylanilides and methods to treat depression | SZMUSZKOVICZ JACOB (US) | 1980-04-22 | — | — | US | disclosed |
| US-4172898-A | N-(2-aminocycloheptyl)acylanilides | THE UPJOHN COMPANY (US) | 1979-10-30 | — | — | US | disclosed |
| US-4169156-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-09-25 | — | — | US | disclosed |
| US-4159339-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4156014-A | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |