Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446446 | 0.93 | HTR6 (0.59) | HTR6ALDH1A1LMNAHTR7MEN1 | |
| SCHEMBL11447087 | 0.89 | HTR7 (0.51) | HTR7MEN1KMT2APOLBGFER | |
| SCHEMBL11500563 | 0.88 | HTR7 (0.57) | HTR6ALDH1A1LMNAHTR7MEN1 | |
| SCHEMBL11447099 | 0.88 | HTR7 (0.52) | HTR7KMT2APOLBGFERDRD3 | |
| SCHEMBL11447935 | 0.88 | POLB (0.60) | HTR6ALDH1A1LMNAHTR7MEN1 | |
| SCHEMBL11457057 | 0.87 | DRD4 (0.59) | HTR6ALDH1A1HTR7MEN1TSHR | |
| SCHEMBL11446750 | 0.87 | POLB (0.47) | HTR7MEN1KMT2APOLBGFER | |
| Hydrochloric Acid SCHEMBL11447560 | 0.87 | HTR7 (0.51) | HTR7KMT2APOLBGFERDRD3 | |
| Hydrochloric Acid SCHEMBL11446653 | 0.87 | POLB (0.61) | HTR6ALDH1A1LMNAHTR7MEN1 | |
| SCHEMBL11446242 | 0.86 | HTR7 (0.47) | HTR7MEN1KMT2APOLBGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |