Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.57 |
| ▸ | DRD5 | P21918 | 4/20 | 0.57 |
| ▸ | HTR2A | P28223 | 9/20 | 0.52 |
| ▸ | HTR2C | P28335 | 9/20 | 0.52 |
| ▸ | HTR2B | P41595 | 9/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692418 | 0.92 | HTR2A (0.62) | DRD1DRD5HTR2AHTR2CHTR2B | |
| SCHEMBL7621209 | 0.82 | DRD1 (0.81) | DRD1DRD5MAPK1KMT2AMEN1 | |
| SCHEMBL7620194 | 0.82 | DRD1 (0.81) | DRD1DRD5MAPK1KMT2AMEN1 | |
| SCHEMBL7320752 | 0.82 | DRD1 (0.81) | DRD1DRD5MAPK1KMT2AMEN1 | |
| SCHEMBL11454381 | 0.81 | DRD1 (0.67) | DRD1DRD5MAPK1ALDH1A1ADCY5 | |
| Bromide SCHEMBL11452838 | 0.80 | DRD1 (0.67) | DRD1DRD5MAPK1ALDH1A1ADCY5 | |
| SCHEMBL11452004 | 0.79 | DRD1 (0.55) | DRD1DRD5HTR2AHTR2CHTR2B | |
| SCHEMBL10690380 | 0.78 | DRD1 (0.71) | DRD1DRD5MAPK1ALDH1A1ADCY5 | |
| SCHEMBL11609656 | 0.78 | DRD1 (0.60) | DRD1DRD5HTR2AHTR2CHTR2B | |
| Bromide SCHEMBL10691988 | 0.77 | DRD1 (0.72) | DRD1DRD5MAPK1ALDH1A1ADCY5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4187314-A | DOPAMINERGIC ACTIVITY | SMITHKLINE CORPORATION (US) | 1980-02-05 | — | — | US | disclosed |
| US-4111957-A | DOPAMINERGIC | SMITHKLINE CORPORATION (US) | 1978-09-05 | — | — | US | disclosed |