Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 3/20 | 0.35 |
| ▸ | ALPI | P09923 | 3/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTR1E | P28566 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508918 | 0.81 | VCAM1 (0.39) | ALPLALPIVCAM1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11465083 | 0.77 | APEX1 (0.37) | MAPTMEN1KMT2AS1PR3 | |
| SCHEMBL11452734 | 0.74 | PTGS2 (0.37) | SMN1; SMN2MAPTMEN1KMT2AHTT | |
| SCHEMBL11461875 | 0.72 | MAPT (0.38) | SMN1; SMN2RAB9AALDH1A1MAPTMCOLN3 | |
| SCHEMBL11463589 | 0.67 | MAP3K14 (0.43) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL11454347 | 0.66 | MAP3K14 (0.41) | SMN1; SMN2MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL11472733 | 0.66 | MAPT (0.43) | SMN1; SMN2ALDH1A1MAPTMCOLN3MEN1 | |
| SCHEMBL11462608 | 0.66 | GCGR (0.39) | SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL11510235 | 0.66 | MAPT (0.42) | SMN1; SMN2ALDH1A1MAPTRECQLMEN1 | |
| SCHEMBL11459956 | 0.65 | MAP3K14 (0.41) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4207325-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE AND ANTITHROMBOTIC PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 1980-06-10 | — | — | US | disclosed |
| US-4113872-A | DIURETICS, SALURETICS, ANTIHYPERTENSIVE, ANTITHROMBOTIC AGENTS | BAKER AKTIENGESELLSHAFT (DE) | 1978-09-12 | — | — | US | disclosed |
| US-4112109-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |