Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 8/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 2/20 | 0.33 |
| ▸ | CMA1 | P23946 | 2/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11509098 | 0.78 | APEX1 (0.36) | APEX1S1PR1S1PR3CTSGCMA1 | |
| SCHEMBL11453152 | 0.77 | ALPL (0.35) | S1PR3MEN1KMT2AMAPT | |
| SCHEMBL11452734 | 0.72 | PTGS2 (0.37) | MEN1KMT2AMAPT | |
| SCHEMBL11465090 | 0.71 | MAP3K14 (0.41) | S1PR1S1PR3MAP3K14MEN1KMT2A | |
| SCHEMBL11463589 | 0.69 | MAP3K14 (0.43) | MAP3K14MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL11507010 | 0.69 | CNR1 (0.34) | PTGS1MEN1KMT2A | |
| SCHEMBL11454237 | 0.68 | KMT2A (0.36) | MEN1KMT2AMAPT | |
| SCHEMBL11454347 | 0.67 | MAP3K14 (0.41) | MAP3K14MEN1KMT2AMAPT | |
| SCHEMBL11459956 | 0.67 | MAP3K14 (0.41) | MAP3K14MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL11596474 | 0.67 | MAP3K14 (0.41) | MAP3K14MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4207325-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE AND ANTITHROMBOTIC PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 1980-06-10 | — | — | US | disclosed |
| US-4113872-A | DIURETICS, SALURETICS, ANTIHYPERTENSIVE, ANTITHROMBOTIC AGENTS | BAKER AKTIENGESELLSHAFT (DE) | 1978-09-12 | — | — | US | disclosed |
| US-4112109-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4099011-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-07-04 | — | — | US | disclosed |