SCHEMBL4418633

SCHEMBL4418633

O=c1[nH]c(=S)[nH]cc1Cc1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.53
CYP2C9 P11712 1/20 0.53
HPGD P15428 1/20 0.53
DPYD Q12882 1/20 0.48
PNP P00491 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11458310 0.85 DAO (0.50) ALDH1A1CYP2C9HPGDDPYDPNP
SCHEMBL7010634 0.83 PNP (0.51) ALDH1A1CYP2C9HPGDPNPKMT2A
SCHEMBL4423230 0.83 DAO (0.51) MEN1KMT2A
SCHEMBL11450005 0.83 KMT2A (0.49) ALDH1A1KMT2A
SCHEMBL1752654 0.82 DPYD (0.65) DPYD
SCHEMBL11456064 0.82 DAO (0.44) ALDH1A1CYP2C9HPGDMEN1KMT2A
SCHEMBL10979560 0.82 DAO (0.44) ALDH1A1CYP2C9HPGDMEN1KMT2A
SCHEMBL7007907 0.82 PNP (0.55) PNP
SCHEMBL11458528 0.82 DAO (0.47) DPYDKMT2A
SCHEMBL11448290 0.82 PNP (0.54) DPYDPNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8841062-B2 Positive working photosensitive material AZ ELECTRONIC MATERIALS (LUXEMBOURG) S.A.R.L. (LU) 2014-09-23 US claimed
US-20140154624-A1 POSITIVE WORKING PHOTOSENSITIVE MATERIAL AZ ELECTRONIC MATERIALS (LUXEMBOURG) S.A.R.L. (US) 2014-06-05 US claimed
US-4002479-A ORGANIC SILVER SALT, SILVER HALIDE, AND A REDUCING AGENT FUJI PHOTO FILM CO., LTD. (JA) 1977-01-11 US claimed
US-12619149-B2 DNQ-free chemically amplified resist composition MERCK PATENT GMBH (DE) 2026-05-05 US disclosed
US-12393115-B2 Positive working photosensitive material MERCK PATENT GMBH (DE) 2025-08-19 US disclosed
US-20250244669-A1 COMPOSITIONS AND METHODS OF IMPROVING METAL STRUCTURE FABRICATION BY WET CHEMICAL ETCH EMD PERFORMANCE MATERIALS CORP. 2025-07-31 US disclosed
US-12360453-B2 PAG-free positive chemically amplified resist composition and methods of using the same MERCK PATENT GMBH (DE) 2025-07-15 US disclosed
EP-4433873-A2 COMPOSITIONS AND METHODS FOR IMPROVING METAL STRUCTURE FABRICATION BY WET CHEMICAL ETCH Merck Patent GmbH (DE) 2024-09-25 EP disclosed
US-20240045333-A1 POSITIVE-WORKING PHOTORESIST COMPOSITION WITH IMPROVED PATTERN PROFILE AND DEPTH OF FOCUS (DOF) MERCK PATENT GMBH (DE) 2024-02-08 US disclosed
US-11822242-B2 DNQ-type photoresist composition including alkali-soluble acrylic resins MERCK PATENT GMBH (DE) 2023-11-21 US disclosed
EP-4275093-A1 POSITIVE-WORKING PHOTORESIST COMPOSITION WITH IMPROVED PATTERN PROFILE AND DEPTH OF FOCUS (DOF) Merck Patent GmbH (DE) 2023-11-15 EP disclosed
EP-1028955-B1 PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SMITHKLINE BEECHAM PLC (GB) 2003-07-16 EP disclosed
US-20020120139-A1 Pyrimidinone compounds and pharmaceutical compositions containing them HICKEY DEIRDRE MARY BERNADETTE (GB) 2002-08-29 US disclosed
US-6417192-B1 DRUGS WITH PYRIMIDONE COMPOUNDS INHIBITORS OF THE ENZYME LDL PLA.SUB.2 AND THEREFORE OF USE IN TREATING ATHEROSCLEROSIS. SMITHKLINE BEECHAM P.L.C. (GB) 2002-07-09 US disclosed
CN-1352637-A Process for preparing MKC-442 TRIANGLE PHARMACEUTICALS INC (US) 2002-06-05 CN disclosed
EP-1169310-A1 PROCESS FOR PREPARING MKC-442 Triangle Pharmaceuticals Inc. (US) 2002-01-09 EP disclosed
WO-2000061566-A1 PROCESS FOR PREPARING MKC-442 TRIANGLE PHARMACEUTICALS, INC. (US) 2000-10-19 WO disclosed
EP-1028955-A1 PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SmithKline Beecham p.l.c. (GB) 2000-08-23 EP disclosed
WO-1999024420-A1 PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SMITHKLINE BEECHAM PLC (GB) 1999-05-20 WO disclosed
US-4002479-A ORGANIC SILVER SALT, SILVER HALIDE, AND A REDUCING AGENT FUJI PHOTO FILM CO., LTD. (JA) 1977-01-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020120139-A1 Pyrimidinone compounds and pharmaceutical compositions containing them PLA2G7, PLA2G1B, PLA2G4C ALDH1A1 960/4885CYP2C9 1616/4885HPGD 244/4885
US-12619149-B2 DNQ-free chemically amplified resist composition POLQ, RECQL, RPA1 ALDH1A1 983/4885CYP2C9 3539/4885HPGD 2411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.