Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 6/20 | 0.44 |
| ▸ | RPS27 | P42677 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1146382 | 0.85 | MAPK8 (0.57) | MAPK8MAPK9MAPK10GAAL3MBTL1 | |
| SCHEMBL4196059 | 0.83 | KDM4E (0.49) | MAPK8MAPK9MAPK10GAAL3MBTL1 | |
| SCHEMBL1146103 | 0.79 | XDH (0.54) | XDH | |
| SCHEMBL6172803 | 0.78 | L3MBTL1 (0.49) | GAAL3MBTL1KDM4EMAPTTDP1 | |
| SCHEMBL1145995 | 0.78 | GAA (0.54) | MAPK8MAPK9MAPK10GAAL3MBTL1 | |
| SCHEMBL10371014 | 0.76 | L3MBTL1 (0.55) | MAPK8MAPK9MAPK10GAAL3MBTL1 | |
| SCHEMBL2230830 | 0.74 | L3MBTL1 (0.61) | MAPK8MAPK9MAPK10GAAL3MBTL1 | |
| SCHEMBL10367588 | 0.74 | FDPS (0.39) | MAPK8MAPK9MAPK10GAAL3MBTL1 | |
| SCHEMBL12870164 | 0.74 | KDM4E (0.51) | L3MBTL1KDM4EMAPTTDP1XDH | |
| SCHEMBL25049213 | 0.73 | FDPS (0.43) | MAPK10GAAL3MBTL1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888374-B2 | Inhibitors of c-jun N-terminal kinases | ABBOTT LABORATORIES (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888374-B2 | Inhibitors of c-jun N-terminal kinases | ABBOTT LABORATORIES (US) | 2011-02-15 | — | — | US | disclosed |
| WO-2006083673-A2 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF C-JUN N-TERMINAL KINASES | ABBOTT LABORATORIES (US) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | ABBVIE INC. | 2006-08-03 | — | — | US | disclosed |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | ABBVIE INC. | 2006-08-03 | — | — | US | disclosed |
| EP-0186049-B1 | N-SUBSTITUTED AZIRIDINE-2-CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AS WELL AS MEDICAMENTS CONTAINING THESE SUBSTANCES | Roche Diagnostics GmbH (DE) | 1990-07-04 | — | — | EP | disclosed |
| US-4826858-A | IMMUNO-STIMULATING AND IMMUNO-MODULATING ACTIVATIES | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-02 | — | — | US | disclosed |
| EP-0186049-A1 | N-substituted aziridine-2-carboxylic acid derivatives, process for their preparation as well as medicaments containing these substances | Roche Diagnostics GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | MAPKAPK3, MAP3K3, MAPK3 | MAPK8 30/4885MAPK9 49/4885MAPK10 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.