Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 4/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11450303 | 0.96 | SLC6A2 (0.49) | SLC6A2SLC6A4CHRNB4CHRNA3TSHR | |
| SCHEMBL2544615 | 0.85 | CHRNA3 (0.68) | SLC6A2SLC6A4CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL1396836 | 0.85 | CHRNA3 (0.68) | SLC6A2SLC6A4CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL11467927 | 0.82 | CHRNB4 (0.50) | CHRNB4CHRNA3CHRNB2CHRNA4PIM1 | |
| SCHEMBL11456123 | 0.82 | SLC6A2 (0.53) | SLC6A2CHRNB4CHRNA3CYP1A2CYP2D6 | |
| SCHEMBL11466924 | 0.82 | CHRNB4 (0.50) | CHRNB4CHRNA3CHRNB2CHRNA4PIM1 | |
| SCHEMBL11456174 | 0.82 | CHRNB4 (0.74) | CHRNB4CHRNA3L3MBTL1CHRNB2CHRNA4 | |
| SCHEMBL11466925 | 0.82 | CHRNB4 (0.54) | CHRNB4CHRNA3CYP2D6CYP2C19CHRNB2 | |
| SCHEMBL4752609 | 0.81 | LTA4H (0.43) | SLC6A2SLC6A4TSHRCYP1A2CYP2D6 | |
| SCHEMBL5239690 | 0.81 | SSTR2 (0.41) | SLC6A2SLC6A4CHRNB4CHRNA3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225608-A | ANTIDEPRESSANTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-09-30 | — | — | US | disclosed |