Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR2 | P30874 | 7/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705249 | 0.84 | SLC6A2 (0.39) | MKNK1SLC6A2CHRNA3CHRNB4PRKCZ | |
| SCHEMBL12491869 | 0.84 | CHRNB4 (0.39) | MKNK1CHRNA3CHRNB4PRKCZHPGD | |
| SCHEMBL7006966 | 0.83 | CHRNB4 (0.55) | SSTR2CHRNA3CHRNB4PRKCZ | |
| SCHEMBL2172629 | 0.83 | CHRNB4 (0.51) | SSTR2CHRNA3CHRNB4PRKCZHPGD | |
| SCHEMBL5240271 | 0.82 | CHEK2 (0.51) | SSTR2MKNK1CHRNA3CHRNB4HSP90AA1 | |
| SCHEMBL11459124 | 0.81 | SLC6A2 (0.53) | SLC6A2SLC6A4LTA4HCHRNA3CHRNB4 | |
| SCHEMBL6645965 | 0.80 | CHRNB4 (0.44) | SSTR2MKNK1CHRNA3CHRNB4PRKCZ | |
| SCHEMBL6073607 | 0.80 | CHRNB4 (0.47) | SSTR2CHRNA3CHRNB4HSP90AA1HSP90AB1 | |
| SCHEMBL6628961 | 0.80 | CHRNB4 (0.51) | SSTR2CHRNA3CHRNB4HSP90AA1HSP90AB1 | |
| SCHEMBL5261782 | 0.79 | PRKCZ (0.37) | MKNK1LTA4HCHRNA3CHRNB4PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828207-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066174-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-06-22 | — | — | WO | disclosed |