Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17923460 | 0.87 | ALDH1A1 (0.57) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL17923461 | 0.87 | ALDH1A1 (0.57) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7502491 | 0.84 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL11453215 | 0.83 | LMNA (0.54) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL3717856 | 0.80 | ALDH1A1 (0.51) | ALDH1A1GAAPOLBKDM4ETP53 | |
| SCHEMBL10201311 | 0.79 | ALDH1A1 (0.68) | ALDH1A1GAAPOLBKDM4ETP53 | |
| SCHEMBL32691229 | 0.79 | ALDH1A1 (0.68) | ALDH1A1GAAPOLBKDM4ETP53 | |
| SCHEMBL20835844 | 0.79 | ALDH1A1 (0.68) | ALDH1A1GAAPOLBKDM4ETP53 | |
| SCHEMBL512864 | 0.79 | ALDH1A1 (0.68) | ALDH1A1GAAPOLBKDM4ETP53 | |
| SCHEMBL3716759 | 0.79 | ALDH1A1 (0.54) | ALDH1A1GAAPOLBKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4188395-A | 1,4-Dihydropyridine derivatives substituted in the 2 position, and their use as medicaments | BAYER AKTIENGESELLSCHAFT (DE) | 1980-02-12 | — | — | US | disclosed |