Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.58 |
| ▸ | GALR3 | O60755 | 1/20 | 0.58 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11464953 | 1.00 | LMNA (0.58) | LMNAHIF1AGALR3SLC16A3MEN1 | |
| SCHEMBL11465856 | 0.90 | HIF1A (0.60) | LMNAHIF1AGALR3SLC16A3MEN1 | |
| SCHEMBL11465855 | 0.90 | HIF1A (0.60) | LMNAHIF1AGALR3SLC16A3MEN1 | |
| SCHEMBL11467407 | 0.87 | ADRB2 (0.61) | ADRB2ADRB1ADRB3KDM4EGAA | |
| SCHEMBL11467406 | 0.87 | ADRB2 (0.61) | ADRB2ADRB1ADRB3KDM4EGAA | |
| SCHEMBL10604963 | 0.87 | ADRB2 (0.67) | LMNAHIF1AADRB2ADRB1ADRB3 | |
| SCHEMBL11467453 | 0.86 | ADRB2 (0.54) | LMNAHIF1AGALR3MEN1KMT2A | |
| SCHEMBL11467451 | 0.86 | ADRB2 (0.54) | LMNAHIF1AGALR3MEN1KMT2A | |
| Bromide SCHEMBL11470044 | 0.86 | ADRB2 (0.59) | ADRB2ADRB1ADRB3KDM4EGAA | |
| Bromide SCHEMBL11470045 | 0.86 | ADRB2 (0.59) | ADRB2ADRB1ADRB3KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007716-A1 | R-N-(2-phenyl-2-hydroxyethyl)-3-phenylpropyl amines, their formulations, use and preparation | ELI LILLY AND COMPANY (US) | 1980-02-06 | — | — | EP | claimed |
| EP-0007716-A1 | R-N-(2-phenyl-2-hydroxyethyl)-3-phenylpropyl amines, their formulations, use and preparation | ELI LILLY AND COMPANY (US) | 1980-02-06 | — | — | EP | disclosed |