Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 5/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 11/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11477457 | 0.86 | ADRB3 (0.72) | ADRB3ADRB2ADRB1NR3C1CYP2D6 | |
| SCHEMBL11468576 | 0.81 | ADRB2 (0.58) | ADRB3ADRB2ADRB1NR3C1CYP2D6 | |
| SCHEMBL11464927 | 0.81 | ADRB3 (0.82) | ADRB3ADRB2ADRB1NR3C1CYP2D6 | |
| SCHEMBL11507196 | 0.79 | ADRB2 (0.66) | ADRB3ADRB2ADRB1NR3C1CYP2D6 | |
| SCHEMBL22279175 | 0.78 | KMT2A (0.66) | ADRB3ADRB2ADRB1KMT2AADRA1A | |
| SCHEMBL11475095 | 0.77 | CYP2D6 (0.67) | ADRB3ADRB2ADRB1NR3C1CYP2D6 | |
| SCHEMBL11364046 | 0.75 | ADRB2 (0.73) | ADRB3ADRB2ADRB1KMT2AADRA1A | |
| SCHEMBL27773039 | 0.74 | ADRB2 (0.68) | ADRB3ADRB2ADRB1NR3C1CYP2D6 | |
| SCHEMBL11472715 | 0.73 | ADRB3 (0.62) | ADRB3ADRB2ADRB1KMT2ANR3C1 | |
| SCHEMBL11355780 | 0.73 | ATM (0.59) | ADRB3ADRB2ADRB1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007294-A2 | Membrane stabilizing compounds having beta-receptor blocking activity, their preparation, method for treatment of arrhythmic conditions, and pharmaceutical preparations containing same | Aktiebolaget Hässle (SE) | 1980-01-23 | — | — | EP | disclosed |