Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.66 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | NPY1R | P25929 | 1/20 | 0.57 |
| ▸ | NPY2R | P49146 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11509194 | 0.93 | ADRB2 (0.57) | ADRB2ADRB1NR3C1CYP2D6ADRA1A | |
| SCHEMBL11468576 | 0.86 | ADRB2 (0.58) | ADRB2ADRB1NR3C1CYP2D6ADRA1A | |
| SCHEMBL11506733 | 0.86 | ADRB2 (0.66) | ADRB2ADRB1NR3C1CYP2D6ADRA1A | |
| SCHEMBL2615170 | 0.86 | ADRB2 (0.66) | ADRB2ADRB1NR3C1CYP2D6ADRA1A | |
| SCHEMBL11506652 | 0.85 | ADRB2 (0.65) | ADRB2ADRB1NR3C1CYP2D6ADRA1A | |
| SCHEMBL11506632 | 0.84 | ADRB2 (0.63) | ADRB2ADRB1NR3C1CYP2D6ADRA1A | |
| SCHEMBL11848235 | 0.83 | ADRB2 (0.56) | ADRB2ADRB1NR3C1CYP2D6ADRA1A | |
| SCHEMBL11847396 | 0.83 | ABCB1 (0.53) | ADRB2ADRB1 | |
| SCHEMBL11557902 | 0.81 | ADRB2 (0.64) | ADRB2ADRB1NR3C1CYP2D6ADRA1A | |
| SCHEMBL11848223 | 0.81 | ADRB2 (0.48) | ADRB2ADRB1CYP2D6ADRA1APMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4145442-A | ADRENERGIC STIMULANTS; ANTAGONIST, ANTAGONISM | AKTIEBOLAGET HASSLE (SE) | 1979-03-20 | — | — | US | disclosed |
| US-3996382-A | Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases | AKTIEBOLAGET HASSLE (SW) | 1976-12-07 | — | — | US | disclosed |