Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11471319 | 0.92 | MAPT (0.37) | PTGESMAPTALDH1A1MAPK1GFER | |
| SCHEMBL11239685 | 0.89 | PTGES (0.50) | PTGESCACNA2D1PTGS2PDE4BPDE4D | |
| SCHEMBL11476600 | 0.85 | ALDH1A1 (0.41) | PTGESMAPTALDH1A1MAPK1GAA | |
| SCHEMBL2392152 | 0.83 | PTGES (0.48) | PTGESPTGS2MAPTALDH1A1MAPK1 | |
| SCHEMBL11467948 | 0.81 | PTGES (0.35) | PTGESMAPTALDH1A1MAPK1GAA | |
| SCHEMBL11483014 | 0.80 | NQO1 (0.48) | CACNA2D1MAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL11244627 | 0.79 | ADK (0.38) | MAPTALDH1A1GFERSMN1; SMN2KDM4E | |
| SCHEMBL11483047 | 0.79 | PTGES (0.41) | PTGESMAPTALDH1A1MAPK1GFER | |
| SCHEMBL10943076 | 0.79 | MAPT (0.44) | CACNA2D1MAPTALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL11485833 | 0.78 | PTGES (0.51) | PTGESCACNA2D1PTGS2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |