Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.35 |
| ▸ | MET | P08581 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30527364 | 0.85 | BCHE (0.36) | RIPK3METBCHERIPK2MAPT | |
| SCHEMBL31456662 | 0.84 | GAA (0.45) | MEN1MAPTKMT2AHTTGAA | |
| SCHEMBL4698911 | 0.74 | HCAR1 (0.35) | — | |
| SCHEMBL9109139 | 0.74 | MMP8 (0.42) | RIPK3METBCHERIPK2MEN1 | |
| SCHEMBL16812373 | 0.74 | BCHE (0.38) | RIPK3METBCHERIPK2MEN1 | |
| SCHEMBL25233228 | 0.73 | RIPK3 (0.45) | RIPK3METRIPK2MEN1MAPT | |
| SCHEMBL30174215 | 0.72 | KDM4E (0.45) | RIPK3METRIPK2TYK2KDM4E | |
| SCHEMBL4710508 | 0.70 | RXFP1 (0.41) | METMAPTALDH1A1 | |
| SCHEMBL22761934 | 0.69 | PTGS1 (0.57) | HSP90AA1MAPTKMT2AKDM4EHTT | |
| SCHEMBL25529179 | 0.69 | RIPK3 (0.47) | RIPK3METRIPK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225601-A | 3-Hydroxy or hydroxymethyl-5-(4-pyridinyl)2(1H)-pyridinones, useful as cardiotonic agents and their preparation | STERLING DRUG INC. (US) | 1980-09-30 | — | — | US | disclosed |