Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003874 | 0.83 | LMNA (0.39) | RXFP1MAPTPOLBLMNATP53 | |
| SCHEMBL2991826 | 0.81 | ALDH1A1 (0.39) | RXFP1MAPTPOLBLMNATP53 | |
| SCHEMBL1028959 | 0.78 | RXFP1 (0.46) | RXFP1MAPTPOLBF10ALDH1A1 | |
| SCHEMBL4445693 | 0.75 | TUBB4A (0.43) | RXFP1MAPTTP53THRBALDH1A1 | |
| SCHEMBL30104800 | 0.74 | F10 (0.43) | F2F10ALDH1A1 | |
| SCHEMBL632873 | 0.74 | F10 (0.43) | F2F10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4999286 | 0.73 | F10 (0.42) | F2F10ALDH1A1 | |
| SCHEMBL22761934 | 0.71 | PTGS1 (0.57) | RXFP1MAPTLMNAALDH1A1 | |
| SCHEMBL11468996 | 0.70 | RIPK3 (0.35) | MAPTMETALDH1A1 | |
| SCHEMBL1027648 | 0.69 | ALDH1A1 (0.39) | F10ALDH1A1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824844-B1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1824844-B1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1824844-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2007-08-29 | — | — | EP | disclosed |
| US-20060287315-A1 | Pyrazinedicarboxamides and their use | BAYER HEALTHCARE AG (DE) | 2006-12-21 | — | — | US | disclosed |
| WO-2006061116-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-06-15 | — | — | WO | disclosed |
| WO-2006061116-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287315-A1 | Pyrazinedicarboxamides and their use | PEPD, AADAC, PYCARD | RXFP1 3734/4885MAPT 4489/4885POLB 3588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.