Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11536251 | 0.94 | CASP1 (0.33) | CYP2D6DRD2DRD4OPRM1DRD3 | |
| SCHEMBL11530730 | 0.86 | CYP2D6 (0.56) | CYP2D6DRD2DRD4OPRM1DRD3 | |
| SCHEMBL11470978 | 0.84 | OPRM1 (0.48) | CYP2D6DRD2DRD4OPRM1DRD3 | |
| SCHEMBL11534061 | 0.81 | CASP1 (0.34) | CYP2D6DRD2DRD4OPRM1DRD3 | |
| SCHEMBL11537461 | 0.80 | KCNA3 (0.41) | CYP2D6SIGMAR1SLC6A4 | |
| SCHEMBL11533486 | 0.80 | ALDH1A1 (0.39) | CYP2D6DRD2DRD4OPRM1DRD3 | |
| SCHEMBL11536775 | 0.80 | EBP (0.50) | CYP2D6DRD2DRD4OPRM1DRD3 | |
| SCHEMBL11532046 | 0.79 | CYP2D6 (0.46) | CYP2D6DRD2DRD4OPRM1DRD3 | |
| SCHEMBL11533529 | 0.78 | TAAR1 (0.36) | CYP2D6DRD2DRD4OPRM1DRD3 | |
| Hydrochloric Acid SCHEMBL10920199 | 0.77 | SIGMAR1 (0.48) | CYP2D6DRD2DRD4OPRM1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4153797-A | α-Aryl-α, α-bis[ω- (disubstituted amino)alkyl]acetamides and related compounds | G. D. SEARLE & CO. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4107205-A | α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]acetamides and related compounds | G. D. SEARLE & CO. (US) | 1978-08-15 | — | — | US | disclosed |