Mespiperone

Mespiperone

SCHEMBL1901596

CN1CN(c2ccccc2)C2(CCN(CCCC(=O)c3ccc(F)cc3)CC2)C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 1.00
DRD4 P21917 2/20 1.00
HTR2A P28223 2/20 1.00
DRD3 P35462 2/20 1.00
TP53 P04637 2/20 0.71
CYP1A2 P05177 2/20 0.71
CYP3A4 P08684 2/20 0.71
CYP2D6 P10635 2/20 0.71
TSHR P16473 2/20 0.71
MAPK1 P28482 2/20 0.71
CYP2C19 P33261 2/20 0.71
MEN1 O00255 1/20 0.71
MAPT P10636 1/20 0.71
ALOX15 P16050 1/20 0.71
KMT2A Q03164 1/20 0.71
SMN1; SMN2 Q16637 1/20 0.71
NPC1 O15118 1/20 0.71
USP2 O75604 1/20 0.71
LMNA P02545 1/20 0.71
HLA-A P04439 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mespiperone SCHEMBL10733631 0.99 DRD2 (0.98) DRD2DRD4HTR2ADRD3TP53
Hydrochloric Acid SCHEMBL10735573 0.89 DRD2 (0.81) DRD2DRD4HTR2ADRD3TP53
SCHEMBL29462918 0.88 DRD2 (0.79) DRD2DRD4HTR2ADRD3TP53
Hydrochloric Acid SCHEMBL30050104 0.87 DRD2 (0.76) DRD2DRD4HTR2ADRD3TP53
SCHEMBL318990 0.86 DRD2 (0.75) DRD2DRD4HTR2ADRD3TP53
SCHEMBL30405289 0.85 DRD2 (0.74) DRD2DRD4HTR2ADRD3TP53
SCHEMBL13913639 0.85 DRD2 (0.74) DRD2DRD4HTR2ADRD3TSHR
SCHEMBL10692044 0.85 DRD2 (0.73) DRD2DRD4HTR2ADRD3TP53
SCHEMBL8985957 0.84 DRD2 (0.73) DRD2DRD4HTR2ADRD3TP53
SCHEMBL29430174 0.84 MEN1 (1.00) DRD2DRD4HTR2ADRD3TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12514937-B2 Methods for detecting CCR2 receptors WASHINGTON UNIVERSITY (US) 2026-01-06 US claimed
WO-2025226286-A1 SYSTEMS AND METHODS FOR SIMULTANEOUS IMAGING OF MULTIPLE POSITRON EMISSION TOMOGRAPHY (PET) TRACERS MULTIF UNCTIONAL IMAGING LLC (US) 2025-10-30 WO claimed
US-20250329024-A1 SYSTEMS AND METHODS FOR SIMULTANEOUS IMAGING OF MULTIPLE POSITRON EMISSION TOMOGRAPHY (PET) TRACERS MultiFunctional Imaging LLC (US) 2025-10-23 US claimed
US-20240299598-A1 METHODS FOR DETECTING CCR2 RECEPTORS WASHINGTON UNIVERSITY (US) 2024-09-12 US claimed
US-12016935-B2 Methods for detecting CCR2 receptors WASHINGTON UNIVERSITY (US) 2024-06-25 US claimed
US-20230414575-A1 MK2 ACTIVATING COMPOUNDS FOR USE IN TREATING VASCULAR LEAK AND ENDOTHELIAL BARRIER DISORDERS AKTTYVA THERAPEUTICS INC (US) 2023-12-28 US claimed
EP-4244341-A2 MK2 ACTIVATING COMPOUNDS FOR USE IN TREATING VASCULAR LEAK AND ENDOTHELIAL BARRIER DISORDERS Akttyva Therapeutics, Inc. (US) 2023-09-20 EP claimed
US-20230068052-A1 ELUENT SOLUTION GE HEALTHCARE LTD (GB) 2023-03-02 US claimed
WO-2022104097-A2 MK2 ACTIVATING COMPOUNDS FOR USE IN TREATING VASCULAR LEAK AND ENDOTHELIAL BARRIER DISORDERS AKTTYVA THERAPEUTICS, INC. (US) 2022-05-19 WO claimed
US-11111199-B2 Methods for preparing formaldehyde from carbon dioxide THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2021-09-07 US claimed
US-20200405889-A1 METHODS FOR DETECTING CCR2 RECEPTORS WASHINGTON UNIVERSITY (US) 2020-12-31 US claimed
US-20200317594-A1 METHODS FOR PREPARING FORMALDEHYDE FROM CARBON DIOXIDE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2020-10-08 US claimed
CN-107530455-A With automatic biological label production system associated with dosage synthesize card ABT分子成像公司 2018-01-02 CN claimed
US-20170348442-A1 COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS WASHINGTON UNIVERSITY (US) 2017-12-07 US claimed
US-5808020-A Optical reaction cell and light source for 18F! fluoride radiotracer synthesis ASSOCIATED UNIVERSITIES, INC. (US) 1998-09-15 US claimed
EP-4105935-B1 DESIGN OF MOLECULES RECURSION PHARMACEUTICALS INC (US) 2026-05-27 EP disclosed
US-12633373-B2 Systems and methods to predict structures and properties of biomolecule-ligand complexes and uses thereof THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2026-05-19 US disclosed
EP-0393838-A1 Dopamine receptor ligands and imaging agents THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1990-10-24 EP disclosed
US-4772791-A Neuroreceptor activity assessment JOHNS HOPKINS UNIVERSITY (US) 1988-09-20 US disclosed
US-4712561-A Neuroreceptor activity assessment JOHNS HOPKINS UNIVERSITY (US) 1987-12-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170348442-A1 COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS CCR2, CCR1, CCR3 DRD2 2233/4885DRD4 3342/4885HTR2A 663/4885
US-20200405889-A1 METHODS FOR DETECTING CCR2 RECEPTORS CCR2, CCR1, CCR5 DRD2 2085/4885DRD4 3074/4885HTR2A 733/4885
US-12016935-B2 Methods for detecting CCR2 receptors CCR2, CCR1, CCR5 DRD2 2085/4885DRD4 3074/4885HTR2A 733/4885
US-20230068052-A1 ELUENT SOLUTION ABCB11, IPO5, PFAS DRD2 2108/4885DRD4 1584/4885HTR2A 4058/4885
US-11111199-B2 Methods for preparing formaldehyde from carbon dioxide FHIT, FBL, ALKBH3 DRD2 2603/4885DRD4 1431/4885HTR2A 3124/4885
US-20200317594-A1 METHODS FOR PREPARING FORMALDEHYDE FROM CARBON DIOXIDE FHIT, FBL, ALKBH3 DRD2 2603/4885DRD4 1431/4885HTR2A 3124/4885
US-12633373-B2 Systems and methods to predict structures and properties of biomolecule-ligand complexes and uses thereof FABP1, ILK, MAX DRD2 3483/4885DRD4 3190/4885HTR2A 2314/4885
US-20240299598-A1 METHODS FOR DETECTING CCR2 RECEPTORS CCR2, CCR1, CCR5 DRD2 2085/4885DRD4 3074/4885HTR2A 733/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.