SCHEMBL1148360

SCHEMBL1148360

Cc1cc(Cl)cc(C(=O)NC(C)C2CC2)c1NC(=O)C1CC(OS(=O)(=O)c2cccc([N+](=O)[O-])c2)=NN1c1ncccc1Cl

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GPR17 Q13304 10/20 0.36
P2RY2 P41231 4/20 0.35
MALT1 Q9UDY8 2/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
HTT P42858 2/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
F2 P00734 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
MAPK1 P28482 1/20 0.32
FLT1 P17948 1/20 0.32
FLT4 P35916 1/20 0.32
KDR P35968 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1148301 0.94 MALT1 (0.35) GPR17P2RY2MALT1MEN1KMT2A
SCHEMBL1148232 0.93 GPR17 (0.35) GPR17P2RY2MALT1MEN1KMT2A
SCHEMBL1147738 0.91 GPR17 (0.37) GPR17P2RY2MEN1KMT2AHTT
SCHEMBL1148464 0.91 GPR17 (0.38) GPR17P2RY2MALT1MEN1KMT2A
SCHEMBL590218 0.90 MALT1 (0.37) MALT1MAPTSMN1; SMN2
SCHEMBL1148277 0.89 MALT1 (0.35) MALT1ALDH1A1MAPTF2
SCHEMBL1148185 0.89 TSHR (0.37) MALT1HTT
SCHEMBL1148325 0.89 MALT1 (0.37) MALT1
SCHEMBL1147730 0.88 F2 (0.36) GPR17P2RY2MALT1MEN1KMT2A
SCHEMBL1148544 0.88 GPR17 (0.33) GPR17P2RY2MALT1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2264021-B1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-06-26 EP disclosed
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2011-02-10 US disclosed
EP-2264021-A1 PROCESS FOR PRODUCING AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110034696-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND SQOR, NOX5, NOX3 GPR17 4172/4885P2RY2 3126/4885MALT1 3967/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.